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    Radiopharmaceuticals

    Byscientist

    Development is complex: Usually are highly cancer specific, high persistent expression throughout the tumor and metastasis, readily accessible on the cell surface, not shed and thoroughly validated. Many isotopes are possible and many targets possible such as Nectin4, DLL3, FAP, Somatostatin receptors, PSMA, Integrins, CXCR4, Claudin 18.2, Norepinephrine transporter, EGFR2. Clearance from tumor will matter…

  • Neurodegenerative Disease (ALS) Etiology hypothesis

    Byscientist

    A classic case of etiology of disease is the incidence of ALS like symptoms in Guam among the local residents called Chamarro. During the Japanese occupation they were very malnourished and had diseases caused by malnutrition. In addition, they were forced to eat Cycad seeds which are toxic if not treated, but it is possible…

  • Treatment of TB

    Byscientist

    Tuberculosis (TB) is the no 1 infectious disease killer all over the world but there has not been much development in new therapeutics till recently. There are 2 ways to address TB. Vaccine and therapeutics. The current vaccine for TB has been BCG which is not very effective in adults is still useful in children…

  • Sparql tool – connect LLM to knowledge graphs

    Byscientist

    Talk to knowledge graph – sparql-tool Use LLM.: Hallucinations (sometimes good for creativity), Outdated knowledge, no access to your data ( trained on public knowledge). Solutions: Fine tuning – retrain the model on domain data RAG – Search: look things up in real time. Claude code looks at searched doc. Vector embeddings: semantic similarity search…

  • Language of Graphics

    Byscientist

    Key IDEA: Chart types are great shortcuts but graphics are really sophisticated visual structures GoFish language for python using the Gestalt grouping principle. It can make graphics or chart that can display the messages that are intentional. .mark() – what shape to draw at each postion and what channels to encode part to whole relationships…

  • Premium price

    Byscientist

    What is the premium that a new product can charge to that of a conventional product that is already in the market. Parts of it depend on marketing…. Sometimes, the market demands that if there is a lot of competition in the market, then the company try’s to undercut the competition for market entrance and…

  • Specialization

    Byscientist

    Many countries try to get specialized in all their special secret sauces. China is into manufacturing since they can get efficiency where others cannot, but other countries may not have so many special characteristics. Only a question: what is the specific character of differentiation at a country level? For example: a high cost of living…

  • DeepSpot

    Byscientist

    Kalin Klonchev – the winner of a competition for AI based data analysis from Broad in 2024 had also created a tool called DeepSpot. Worth looking at for spot analysis of H&E sections by converting a full H&E slide pictures to “spots” which are analyzed. Some good links: DeepSpot paper: https://www.medrxiv.org/content/10.1101/2025.02.09.25321567v1 DeepSpot GitHub repository: https://github.com/ratschlab/DeepSpot…

  • Museums

    Byscientist

    A human instinct seems to support collection. It may have originated from collection of food and collecting for the hard times…but… the collection seems to progress into other objects. A visit to the beach implies collection of shells. Why? It is not clear why any individual collects. Some of it has to do with shiny…