Many pathways to hit in epigenomics to target cancer. The picture is from this article: Dai, W., Qiao, X., Fang, Y. et al. Epigenetics-targeted drugs: current paradigms and future challenges. Sig Transduct Target Ther 9, 332 (2024). https://doi.org/10.1038/s41392-024-02039-0
Everyone is exposed to complex topics and AI LLM based chatbots help in the understanding if a conversation is needed. Another way is to observe it visually. A company is doing is very well and explaining complex things visually. They have taken on complex tasks explaining scientific topics and their illustrations and videos can simplify…
PET is used in drug discovery: PET in patient selection Process: Cyclotron is used, chemistry and formulation and then imaging and analysis. PET Takes time to make the probe: 20 mins to make the probe For brain usually short half life is used – Carbon 11 – 20 minutes, Fluorine 18 109 minutes, Nitrogen 13…
A classic case of etiology of disease is the incidence of ALS like symptoms in Guam among the local residents called Chamarro. During the Japanese occupation they were very malnourished and had diseases caused by malnutrition. In addition, they were forced to eat Cycad seeds which are toxic if not treated, but it is possible…
It is possible to transfer DNA from one cell to another but usually this is done by transfer of small regions of DNA and their transfer. However, larger pieces can be transferred as whole chromosomes that would add significant amount of DNA material. There are several steps involved such as creation of large sequences and…
Relaxin is a 6kd 2 chain peptide hormone produced by ovary and placenta in females tha help remodel connective tissue but also promotes vasodilation and has cardioprotective and renoprotective effects in animal model via Nitric oxide pathway. Relaxin-2 signaling via GPCR RXFP1 has been investigated as a drug for its antifibrotic and vasodilatory actions. RXFP1…
Sometimes it is hard to imagine how many molecules are involved in a common biological pathway but there are thousands of molecules that orchestrate their chemical reactions to sustain life. One such area is the synaptic gap where messages are passed between neurons. This is a very active space where vesicle with messengers cross the…
There has been changes in the neurological conditions overtime, and you might expect that many of the changes may have increased such as all the neurological disorders like Parkinson’s Alzheimer’s, but the true facts are a little different. For example, as expected, the diabetic neuropathy has increased, But what explains the increase in neonatal sepsis…
There are many companies that promise AI for drug discovery such as ChatGPT from OpenAI, Anthropic’s AI suite and Perplexity and there are more companies coming up too. One specific company that is unusual is that it seems to be promising much more deeper understanding of the drug discovery pathways then the others. It can…
Even with E.coli and M.tuberculosis we only know ½ of them. Can you use ML model to define function: as natural language, or molecular interaction or chemical reaction. Function as molecular interaction: protein – protein interaction. Genomics: Learn association between genes (just like words). It is called gLM2. A multi-modal single residue resolution gLM. GLM2…
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