Pharmaceutical

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    PROTAC databases

    Byscientist

    PROTAC (Proteolysis targeting chimera) is fantastic technology that can degrade specific proteins. It uses a small molecule with a capability to bind the protein to be degraded and an active site that binds to E3 ubiquitin ligase. Using the PROTAC pulls the protein into ubiquitin based degradation pathways by ubiquitination of the protein and subsequent…

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    Novel Catalyst

    Byscientist

    There are many reactions in biology that are catalyzed by enzymes but there are other reactions in industrial chemistry that use industrial catalysts which have primarily been platinum based. A paper in Nature https://www.nature.com/articles/s41467-026-68432-1 promises a unique shaped catalyst that can split H-H bond and other reactions. It is a unique structure and promises to…

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    Antifungals

    Byscientist

    There are several antifungals in the market and it is difficult to understand how many more are needed since there are quite a few in the market. One major use is for treatment of Athelete’s foot. Fungi contain cell wall made up of beta-1-3-glucan, other glucans and gylcoprotein. Below the cell wall there is a…

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    Biotech companies

    Byscientist

    Small Biotechs: Diagonal Tx: Clustering antibodies that mimic the action of the ligand and bypass the need for the ligand and receptor. This mutation that is created makes standard AI models not useful and so need a new method. This restores new ALK1 signaling in Hereditary Hemorrhagic Telangiectasia. It also treates LoF mutations in ALK1…

  • Biotech clusters

    Byscientist

    Biotech cluster in Boston/Cambridge Kendall square has become a hub of new Biotech companies. The one developer that has had a major role to play has been David Clem who’s effort has been documented by Robin Wolfe Scheffler – a MIT historian and author of David Clem: Building Genetown. This model is not easy to…

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    Obesity facts

    Byscientist

    Just some highlights to remember 50% of world population is thought to be obesity and thought to be a master switch for a variety of disorders such as diabetes, cardiovascular disease, liver disease and kidney. 30-40% of Diabetics develop chronic kidney diseases and presence of albuminuria raises risk. 38% of adults have MASH with very…

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    Sleep apnea

    Byscientist

    Sleep apnea is when sufferer stops breathing (apnea) at night as the muscles in the throat relax and then resumes when brain semi-awakes when the oxygen supply gets low to restore respiration. This happens tens to hundreds of times at night and can be debilitating when the disruption to sleep causes other health effects such…