This was at Google’s offices in Cambridge, MA learning GCP and Google cloud framework while using AI tools for drug discovery. Thank you to the team members at Google, for helping me understand how to set up an AI workflow and discover drugs by targeting EGFR (Epidermal Growth Factor Receptor) kinase domain. This example is…
Two types of inflammatory bowel disease, Ulcerative colitis and Crohn’s disease. A challenge in IBD development is that many drugs show systemic PK and PD but fail in the intestinal mucosa. Most companies focus on Ulcerative colitis due to a) homogenous biology, b) access to tissue, c) established endpoints and d) lower variability in translational…
From the public pipeline, it appears that the interest is in vascular anomalies Hence the biomarker plan would be the following: The website is : https://relaytx.com
Biomarker plan There is a company that is developing gene therapy for Retina market and Cystic fibrosis called 4DMT. What would its Biomarker plan look like and what would the translational person do at the company? Sometimes it is clear what is needed though specific execution steps and assays can be challenging. The devil is…
There are many companies that offer personalized health solutions to help individuals. Some offer imaging services while others are more specific: for cancer diagnosis or hormone levels. Consider some examples: Personalis: Cancer Biomarker Discovery through liquid biopsy and other precision oncology tools. They have collaborations with many institutions but it is not clear what makes…
If you’re a billionaire, then you’ve got a lot of wealth and access to our resources. However, what you do not have is access to additional years of your life.There has been a wonderful Substack post about how billionaires die. It turns out that most of the death is due to aging and unspecified reasons,…
There have been so many multi-cancer early detection tests coming on the market and the users are generally not aware of them – each of them have a different capability and strengths. Genomeweb had done a survey of what are the tests available and how they are perceived. Look at the survey at : https://www.genomeweb.com/cancer/genomeweb-survey-enthusiasm-mced-tests-research-and-clinical-care-despite-evidence-caveats…
Many pathways to hit in epigenomics to target cancer. The picture is from this article: Dai, W., Qiao, X., Fang, Y. et al. Epigenetics-targeted drugs: current paradigms and future challenges. Sig Transduct Target Ther 9, 332 (2024). https://doi.org/10.1038/s41392-024-02039-0
PROTAC (Proteolysis targeting chimera) is fantastic technology that can degrade specific proteins. It uses a small molecule with a capability to bind the protein to be degraded and an active site that binds to E3 ubiquitin ligase. Using the PROTAC pulls the protein into ubiquitin based degradation pathways by ubiquitination of the protein and subsequent…
When diagnostic tests are implemented in clinical studies there are multiple considerations beyond just the assay and the analyte that are not generally considered but are important. For example: Sample collection, preparation and transport Standards need to be specified for pre-analysis that would specify the conditions needed even before the analysis are done. Selection of…
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