Biomarker

  • Multi-cancer early detection

    Byscientist

    There have been so many multi-cancer early detection tests coming on the market and the users are generally not aware of them – each of them have a different capability and strengths. Genomeweb had done a survey of what are the tests available and how they are perceived. Look at the survey at : https://www.genomeweb.com/cancer/genomeweb-survey-enthusiasm-mced-tests-research-and-clinical-care-despite-evidence-caveats…

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    PROTAC databases

    Byscientist

    PROTAC (Proteolysis targeting chimera) is fantastic technology that can degrade specific proteins. It uses a small molecule with a capability to bind the protein to be degraded and an active site that binds to E3 ubiquitin ligase. Using the PROTAC pulls the protein into ubiquitin based degradation pathways by ubiquitination of the protein and subsequent…

  • Considerations for analysis of clinical samples

    Byscientist

    When diagnostic tests are implemented in clinical studies there are multiple considerations beyond just the assay and the analyte that are not generally considered but are important. For example: Sample collection, preparation and transport Standards need to be specified for pre-analysis that would specify the conditions needed even before the analysis are done. Selection of…

  • Prioritizing biomarkers

    Byscientist

    When there are multiple biomarkers in a therapeutic study, how do you prioritize which one to use. One possibility is to use specific criteria. The easiest one of them is to select one that gives you the best signal/noise. A strong signal for your efficacy marker will enable you to detect small changes in the…

  • Liquid biopsy guidelines

    Byscientist

    A term that was created in 2010 called “liquid biopsy” became the standard for much of the screening of cancer that is done using blood to check for cancer cells though the NCI definition is specific for cancer and used to include its applications in detecting cancer and determining therapeutic efficacy : https://www.cancer.gov/publications/dictionaries/cancer-terms/def/liquid-biopsy The first…

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    Radiopharmaceuticals

    Byscientist

    Development is complex: Usually are highly cancer specific, high persistent expression throughout the tumor and metastasis, readily accessible on the cell surface, not shed and thoroughly validated. Many isotopes are possible and many targets possible such as Nectin4, DLL3, FAP, Somatostatin receptors, PSMA, Integrins, CXCR4, Claudin 18.2, Norepinephrine transporter, EGFR2. Clearance from tumor will matter…

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    Relaxin

    Byscientist

    Relaxin is a 6kd 2 chain peptide hormone produced by ovary and placenta in females tha help remodel connective tissue but also promotes vasodilation and has cardioprotective and renoprotective effects in animal model via Nitric oxide pathway. Relaxin-2 signaling via GPCR RXFP1 has been investigated as a drug for its antifibrotic and vasodilatory actions. RXFP1…