Circolide: We are dependent on fossil carbon for materials around us. Polymeric materials such as acrylate is produced from fossil based materials and used for decorative and functional and usually used as coatings or in plexi-glass materials. This is a $15B + market with 8.6 Metric tons. This molecule is based on fossil feed stock….
PET is used in drug discovery: PET in patient selection Process: Cyclotron is used, chemistry and formulation and then imaging and analysis. PET Takes time to make the probe: 20 mins to make the probe For brain usually short half life is used – Carbon 11 – 20 minutes, Fluorine 18 109 minutes, Nitrogen 13…
Development is complex: Usually are highly cancer specific, high persistent expression throughout the tumor and metastasis, readily accessible on the cell surface, not shed and thoroughly validated. Many isotopes are possible and many targets possible such as Nectin4, DLL3, FAP, Somatostatin receptors, PSMA, Integrins, CXCR4, Claudin 18.2, Norepinephrine transporter, EGFR2. Clearance from tumor will matter…
A classic case of etiology of disease is the incidence of ALS like symptoms in Guam among the local residents called Chamarro. During the Japanese occupation they were very malnourished and had diseases caused by malnutrition. In addition, they were forced to eat Cycad seeds which are toxic if not treated, but it is possible…
Tuberculosis (TB) is the no 1 infectious disease killer all over the world but there has not been much development in new therapeutics till recently. There are 2 ways to address TB. Vaccine and therapeutics. The current vaccine for TB has been BCG which is not very effective in adults is still useful in children…
Talk to knowledge graph – sparql-tool Use LLM.: Hallucinations (sometimes good for creativity), Outdated knowledge, no access to your data ( trained on public knowledge). Solutions: Fine tuning – retrain the model on domain data RAG – Search: look things up in real time. Claude code looks at searched doc. Vector embeddings: semantic similarity search…
Key IDEA: Chart types are great shortcuts but graphics are really sophisticated visual structures GoFish language for python using the Gestalt grouping principle. It can make graphics or chart that can display the messages that are intentional. .mark() – what shape to draw at each postion and what channels to encode part to whole relationships…
What is the premium that a new product can charge to that of a conventional product that is already in the market. Parts of it depend on marketing…. Sometimes, the market demands that if there is a lot of competition in the market, then the company try’s to undercut the competition for market entrance and…
Sometimes, all the links have been compiled so well, that you choose to Bookmark them. In this case, with currently people out of their regular jobs and not so fulfilling jobs available, there is a link being maintained that makes finding the current jobs based on location and expertise easy. https://biopharmguy.com/career-by-name.php Worth checking out the…
Many countries try to get specialized in all their special secret sauces. China is into manufacturing since they can get efficiency where others cannot, but other countries may not have so many special characteristics. Only a question: what is the specific character of differentiation at a country level? For example: a high cost of living…
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