News

  • Biotech clusters

    Byscientist

    Biotech cluster in Boston/Cambridge Kendall square has become a hub of new Biotech companies. The one developer that has had a major role to play has been David Clem who’s effort has been documented by Robin Wolfe Scheffler – a MIT historian and author of David Clem: Building Genetown. This model is not easy to…

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    TDP43

    Byscientist

    TDP43 (a nuclear DNA-RNA binding protein) is involved in splicing, RNA transport and stability in neurons. It was first identified as a pyrimidine rich TAR DNA sequence in HIV type 1 gene to modulate HIV gene expression. In 95% of the ALS patients, TDP43 is abnormal located within the cell and may also be aggregated,…

  • LoRa adaptors

    Byscientist

    LoRa in the IOT community are the low power long range wireless standards devices that are utilized to send a signal over large distances. However, in the AI field LoRa implies Low rank adaptation – which is relatively more efficient compute way to fine tune pretrained models (LLM, vision transformers, diffusion models). With a pretrained…

  • Flow

    Byscientist

    The father of focus was Mihaly Csikszentmihalyi an American Hungarian psychiatrist who associated focus with happiness. His contention was that true happiness comes from doing things in flow. Flow was designed as something that had enough challenge that makes it exciting while at the same time not being boring. For example, passive activities such as…

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    Heart rate variability

    Byscientist

    By definition, heart rate variability is the time between each heart beat. This is called the R-R interval and shows the beat modulation of the sino-atrial node whose time variation is controlled by the autonomic nervous system. This matters because sympathetic (fight or flight) or parasympathetic (rest and digest) activity governs cardiac dynamics. A higher…

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    Knowledge graphs

    Byscientist

    Knowledge graph is a way of representing information where entities/nodes (people, places, products, concepts) are linked by relationships/edges (works, creates, has ). It is a semantic network that captures facts and context. There is also an ontology that defines different types of node/edges and defines what types exist and how they relate. These are used…

  • Polyphenols

    Byscientist

    Polyphenols are a large family of naturally occurring compounds found in plants with two or more aromatic rings bearing one or more OH groups. They are divided into four main subclasses: Flavonoids : Quercetin (onions), catechin (tea), anthocyanins and kaempferol (Onions, berries, tea, dark chocolate) Phenolic acids: Caffeic acid, ferulic acid, ellagic acid, chlorogenic acid…

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    Obesity facts

    Byscientist

    Just some highlights to remember 50% of world population is thought to be obesity and thought to be a master switch for a variety of disorders such as diabetes, cardiovascular disease, liver disease and kidney. 30-40% of Diabetics develop chronic kidney diseases and presence of albuminuria raises risk. 38% of adults have MASH with very…

  • Docker

    Byscientist

    Docker allows developers to deploy their applications in a sandbox to run on a host system with all the dependencies with a very low overhead. Typically that used to be done by virtual machines, but docker makes it more secure and faster without the virtual machine overload. Like any other complex system, there are many…