Explainable AI

A human hand with tattoos reaching out to a robotic hand on a white background.

A very traditional problem solving method is the following: given a set of features or variables, can we understand the features to form a conclusion. This could be something like a treatment strategy wherein the strategy is built on a series of data and then ingesting the data helps make a conclusion. However, an equally complicated question is that given that there are many factors that affect the decision – is there one or few factors that play a key role and changing those factors will affect the decision. Which means that if there are many factors that would affect the decision, can you change/alter that one factor and that would make a change to that decision.

Using AI to ingest a variable factors and then come up with an answer is usually opaque. And therefore finding the key factor is the basis of xAI -explainable AI. It is also called feature attribution. The method to figure this out is SHAP (Shapley addition explanations). One good website for a book chapter is here : https://christophm.github.io/interpretable-ml-book/shap.html

Similar Posts

  • |

    Reinforcement learning

    Reinforcement learning is a method that drives learning and memory in primitive species such as birds, humans and other living species to its use in machine learning. It is used to influence the behavior of us humans on social media to its use to train machines. The essential components were initiated by BF Skinner 20th…

  • AI job search

    With AI enabling many activities in the job hunt process, it is expected that many job applicants and executive at hiring companies use AI based tools for the process. The “automated” process used to be enabled by keywords which was the way that the candidates were selected from a large pool but with the availability…

  • DeepSpot

    Kalin Klonchev – the winner of a competition for AI based data analysis from Broad in 2024 had also created a tool called DeepSpot. Worth looking at for spot analysis of H&E sections by converting a full H&E slide pictures to “spots” which are analyzed. Some good links: DeepSpot paper: https://www.medrxiv.org/content/10.1101/2025.02.09.25321567v1 DeepSpot GitHub repository: https://github.com/ratschlab/DeepSpot…

  • |

    Virtual cell

    Hani Goodrazi – Arc institute has been working on virtual cell. Drugs fail due to overfit experimental models, You need screen drugs with better models of human biology. Geneva is platfrom that brings tumor models into perturbation model – that is a transcriptomics assay that deconvolves into effect. Take multiple cell line and then treat…