Development is complex: Usually are highly cancer specific, high persistent expression throughout the tumor and metastasis, readily accessible on the cell surface, not shed and thoroughly validated. Many isotopes are possible and many targets possible such as Nectin4, DLL3, FAP, Somatostatin receptors, PSMA, Integrins, CXCR4, Claudin 18.2, Norepinephrine transporter, EGFR2. Clearance from tumor will matter…
Sometimes it is hard to imagine how many molecules are involved in a common biological pathway but there are thousands of molecules that orchestrate their chemical reactions to sustain life. One such area is the synaptic gap where messages are passed between neurons. This is a very active space where vesicle with messengers cross the…
Discussion by Manu Leonetti at Chan Zuckerberg hub. Self driving cars are taught in simulation. Similar biology should be also done as simulations. The cell needs to be thought as devices. How does information flow within a cell and do that in cells. Use GFP to tag the cells but also later use it for…
Human PET (Positron Emission Tomography) scanning is used frequently to determine the metabolism of glucose in the body which help find cancer and also for finding specific molecules using specific PET probes. However, PET scanners are expensive to operate, expose the body to radiation and also require long amounts of time for the patient in…
It is typically difficult to map in three dimensions (3D) at a very close distance in high precision very quickly. There are different ways to accurately represent three dimensions but that requires a 3D scanner that will take a number of “images” with light or infrared or sonar and then map it correctly. However, if…
It is difficult to image at high resolution using conventional optics to any reasonable depth below the skin. There are many ways to counteract this and one unique method is called photoacoustic imaging. This method was invented by Lihong Wang at Washington University in St Louis. The phenomenon of acoustic imaging is fascinating use of…
Cheap robots by the millions Typically it costs many hundreds of dollars to make a robot that can do something substantial. However, researchers at the Fraunhofer institute have created molded or stamped robots that can be created very cheaply – they imagine them to be like disposable gloves. Make them, use them and then throw…
A researcher, Ji-Xin Cheng, at Purdue university has figured out a label free method to label carbon nanotubes. Nanotubes are typically hard to see and with Cheng’s technique not only can you see the nanotubes but you can also visualize them within cells. The method is known as transient absorbtion and uses a pulsed near…
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