|

Sequencing

Byscientist
Artistic rendering of a DNA strand with particle effects against a dark background.

It is amazing how good genetic sequencing is getting these days and reasonable enough to get 30x whole genome sequence that enables detailed analysis for a variety of conditions. The costs are so low that it is now possible for almost everyone to do it and also analyze the data.

One provider with a catchy domain name – http://sequencing.com has been offering sequencing and analysis. Worth checking out…

Similar Posts

  • |

    Alzhiemer’s psychosis

    Byscientist

    Alzheimer’s psychosis is distinct from the slow progression of Alzheimer’s and indicates a more severe phenotype in which cognitive decline starts even before psychosis onset. It is thought to originate/localized in neocortex rather than medial temporal lobe. There is currently only one drug that targets Alzheimer’s psychosis. It is called Rexulti (Brexipipazole). It is specifically…

  • |

    Neurological conditions

    Byscientist

    There has been changes in the neurological conditions overtime, and you might expect that many of the changes may have increased such as all the neurological disorders like Parkinson’s Alzheimer’s, but the true facts are a little different. For example, as expected, the diabetic neuropathy has increased, But what explains the increase in neonatal sepsis…

  • |

    Muscarinic drugs and receptors

    Byscientist

    There are many G-protein coupled receptors and one of the major categories for neurological drug development are called muscarinic receptors because they were first known to be activated by a mushroom alkaloid called muscarine. The isolation and characterization of muscarine was first reported by chemists in 1869! Muscarine works by mimicking the neurotransmitter acteylcholine on…

  • |

    Premature ventricular complex

    Byscientist

    PVC Cardiac cycle – Periventricular – Contraction. depolarization. How common are PVC in population. 2-5% number of people had extra beats. Smoe like said 20% Myocyte action potential is complicated Why do PVC occur: Beat occurs little early because: PVC come in different ECG patterns Bigeminy – every other beat Trigenmy every third beat Non…

  • New Cancer targets

    Byscientist

    Targets for cancer therapy initially were very specific cell division targets. Nowadays, the targets have become very cancer specific, for e.g. targeting the BCR-ABL to target Chronic Myeloid Leukemia. However, a scientist in Australia has come up with a target that is very unlikely – tropomyosin. Tropomyosin is a protein that along with actin is…

  • |

    Adeno associated virus

    Byscientist

    Adeno associated virus (AAV) has been one of major interests for gene therapy. AAV was discovered in 1965 as a contaminant of adeno virus and hence the name. It is 22nm and low pathogenicity because no polymerase and cannot replicate till there is co-infector. Genome map is 4.7kb. 145 nucleotides inverted terminal repeats at both…