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Bisphenol A

drum, nature, water, bottle, plastic, 20 litres

There is lot of information on BPA on wikipedia that talks about its use in plastics especially polycarbonates that are used in water bottle manufacturing. Polycarbonate bottles are transparent and can contain 90% BPA by mass It is not a plasticizer.

The concern for its use comes from its effect as a weak xenoestrogen disrupting the normal pathways in human signaling. It is especially important because it is so pervasive such as being used to coat the inside of food cans, on paper receipts and in plastics.

Though it is ~1000 fold less potent than estradiol in binding to estrogen receptors its binding to ERR-Y (estrogen related receptor gamma) is much stronger with a dissociation constant of 5.5nM which regulates other genes.

It degrades in water but the sheer amount of BPA being used as plastics may be a worry.

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