Interest in longevity is increasing. There are many conferences in aging research – almost 2 a month for 2026. For a full list see here:
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Fluorescent living cell produces laser
Harvard Wellman Center for Photo medicine’s two scientists, Gather and Yun, have shown that they can generate laser light from single cells. These HEK293 cells were transiently transfected with GFP. The expressed GFP (~300 microMolar) showed optical amplification of light. The cells had to placed in an artificial cavity and stimulated by external pulsed laser…
Adeno associated virus
Adeno associated virus (AAV) has been one of major interests for gene therapy. AAV was discovered in 1965 as a contaminant of adeno virus and hence the name. It is 22nm and low pathogenicity because no polymerase and cannot replicate till there is co-infector. Genome map is 4.7kb. 145 nucleotides inverted terminal repeats at both…
Reinforcement learning
Reinforcement learning is a method that drives learning and memory in primitive species such as birds, humans and other living species to its use in machine learning. It is used to influence the behavior of us humans on social media to its use to train machines. The essential components were initiated by BF Skinner 20th…
Fitness landscape for antibodies (Flab2)
There have been many AI models to predict the structure of proteins, especially antibodies. There are several key aspects to developing antibodies as drugs beyond binding to the target of interest. These are : thermostability, expression, aggregation, binding affinity, pharmacokinetics, polyreactivity and immunogenicity. There have been many models available such as IgLM, ProGen2, Chai-1, ESM2,…
