News archive

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    Clinical trial challenges

    Byscientist

    Clinical trials are hard to do and often requires the cooperation of the CRO to execute the study, but Also, the study center that is recruiting The participants in the clinical study. The CRO monitors the clinical study but also all the aspects of the clinical study. A company called T3D therapeutics (https://www.t3dtherapeutics.com/) recently had…

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    Mesoscale explorer

    Byscientist

    Sometimes it is hard to imagine how many molecules are involved in a common biological pathway but there are thousands of molecules that orchestrate their chemical reactions to sustain life. One such area is the synaptic gap where messages are passed between neurons. This is a very active space where vesicle with messengers cross the…

  • Judging art

    Byscientist

    Art especially with pencil and paper is the culmination of human esthetic and often times is dependent on the eye of the beholder. Some artwork that is meaningful to one person is not so understandable or sometimes even ugly to the other person. So how do you judge art. There are several ways to do…

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    Neurological conditions

    Byscientist

    There has been changes in the neurological conditions overtime, and you might expect that many of the changes may have increased such as all the neurological disorders like Parkinson’s Alzheimer’s, but the true facts are a little different. For example, as expected, the diabetic neuropathy has increased, But what explains the increase in neonatal sepsis…

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    AI for drug discovery

    Byscientist

    There are many companies that promise AI for drug discovery such as ChatGPT from OpenAI, Anthropic’s AI suite and Perplexity and there are more companies coming up too. One specific company that is unusual is that it seems to be promising much more deeper understanding of the drug discovery pathways then the others. It can…

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    Functional prediction of microbial sequences

    Byscientist

    Even with E.coli and M.tuberculosis we only know ½ of them. Can you use ML model to define function: as natural language, or molecular interaction or chemical reaction. Function as molecular interaction: protein – protein interaction. Genomics: Learn association between genes (just like words). It is called gLM2. A multi-modal single residue resolution gLM. GLM2…

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    Virtual cell

    Byscientist

    Hani Goodrazi – Arc institute has been working on virtual cell. Drugs fail due to overfit experimental models, You need screen drugs with better models of human biology. Geneva is platfrom that brings tumor models into perturbation model – that is a transcriptomics assay that deconvolves into effect. Take multiple cell line and then treat…

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    Open source protein models

    Byscientist

    A company called Profluent (profluent.bio) has been developing protein models that can be used for designing new proteins (https://www.nature.com/articles/s41587-022-01618-2), modeling of new CRISPR-Cas sequences (https://www.nature.com/articles/s41586-025-09298-z) and developing LLM for protein generation (https://www.biorxiv.org/content/10.1101/2025.11.12.688125v1.article-info). What is amazing is that they have open sourced all their models and Profluent-E1 is available in GitHub to download and use. (https://github.com/Profluent-AI/E1)…