Biology

  • |

    Neurological conditions

    Byscientist

    There has been changes in the neurological conditions overtime, and you might expect that many of the changes may have increased such as all the neurological disorders like Parkinson’s Alzheimer’s, but the true facts are a little different. For example, as expected, the diabetic neuropathy has increased, But what explains the increase in neonatal sepsis…

  • |

    AI for drug discovery

    Byscientist

    There are many companies that promise AI for drug discovery such as ChatGPT from OpenAI, Anthropic’s AI suite and Perplexity and there are more companies coming up too. One specific company that is unusual is that it seems to be promising much more deeper understanding of the drug discovery pathways then the others. It can…

  • | |

    Functional prediction of microbial sequences

    Byscientist

    Even with E.coli and M.tuberculosis we only know ½ of them. Can you use ML model to define function: as natural language, or molecular interaction or chemical reaction. Function as molecular interaction: protein – protein interaction. Genomics: Learn association between genes (just like words). It is called gLM2. A multi-modal single residue resolution gLM. GLM2…

  • |

    Virtual cell

    Byscientist

    Hani Goodrazi – Arc institute has been working on virtual cell. Drugs fail due to overfit experimental models, You need screen drugs with better models of human biology. Geneva is platfrom that brings tumor models into perturbation model – that is a transcriptomics assay that deconvolves into effect. Take multiple cell line and then treat…

  • |

    Adeno associated virus

    Byscientist

    Adeno associated virus (AAV) has been one of major interests for gene therapy. AAV was discovered in 1965 as a contaminant of adeno virus and hence the name. It is 22nm and low pathogenicity because no polymerase and cannot replicate till there is co-infector. Genome map is 4.7kb. 145 nucleotides inverted terminal repeats at both…

  • |

    Antifungals

    Byscientist

    There are several antifungals in the market and it is difficult to understand how many more are needed since there are quite a few in the market. One major use is for treatment of Athelete’s foot. Fungi contain cell wall made up of beta-1-3-glucan, other glucans and gylcoprotein. Below the cell wall there is a…

  • | | |

    Biotech companies

    Byscientist

    Small Biotechs: Diagonal Tx: Clustering antibodies that mimic the action of the ligand and bypass the need for the ligand and receptor. This mutation that is created makes standard AI models not useful and so need a new method. This restores new ALK1 signaling in Hereditary Hemorrhagic Telangiectasia. It also treates LoF mutations in ALK1…

  • |

    ALS and TDP43

    Byscientist

    Almost 90% of ALS is thought to be sporadic. The reasons are not well understood and thought to be oxidative stress, damaged endoplasmic reticulum, mitochondria, cytoskeleton or misregulation of RNA pathways. One protein implicated is TDP43 which sits as a junction of ALS pathogenic path by binding to RNA modulation synthesis, splicing, stability and transport….