Another look at the financial data of Pharmaceutical companies. Who has the big bucks to spend on research? A picture is worth a thousand words.

Another look at the financial data of Pharmaceutical companies. Who has the big bucks to spend on research? A picture is worth a thousand words.

AI agents are everywhere accomplishing activities. Drug Discovery agents have been coming on fast and the scale at which these agents approach drug discovery is phenomenal. There is a great example of a AWS agent that was SPECification built using Kiro from scratch in 3 weeks that delivers drug targets. Amazing to see that it…
Biotech cluster in Boston/Cambridge Kendall square has become a hub of new Biotech companies. The one developer that has had a major role to play has been David Clem who’s effort has been documented by Robin Wolfe Scheffler – a MIT historian and author of David Clem: Building Genetown. This model is not easy to…
PROTAC (Proteolysis targeting chimera) is fantastic technology that can degrade specific proteins. It uses a small molecule with a capability to bind the protein to be degraded and an active site that binds to E3 ubiquitin ligase. Using the PROTAC pulls the protein into ubiquitin based degradation pathways by ubiquitination of the protein and subsequent…
Just some highlights to remember 50% of world population is thought to be obesity and thought to be a master switch for a variety of disorders such as diabetes, cardiovascular disease, liver disease and kidney. 30-40% of Diabetics develop chronic kidney diseases and presence of albuminuria raises risk. 38% of adults have MASH with very…
Take an example of failed target validation. Eli Lilly is just one company but this could be true of almost all the pharmaceutical companies. Eli Lilly announced in August 2012, that they have stopped “ongoing clinical studies investigating pomaglumetad methionil, also known as mGlu2/3, for the treatment of patients suffering from schizophrenia” in Phase 3….
Sleep apnea is when sufferer stops breathing (apnea) at night as the muscles in the throat relax and then resumes when brain semi-awakes when the oxygen supply gets low to restore respiration. This happens tens to hundreds of times at night and can be debilitating when the disruption to sleep causes other health effects such…
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