Another look at the financial data of Pharmaceutical companies. Who has the big bucks to spend on research? A picture is worth a thousand words.

Another look at the financial data of Pharmaceutical companies. Who has the big bucks to spend on research? A picture is worth a thousand words.

There are several antifungals in the market and it is difficult to understand how many more are needed since there are quite a few in the market. One major use is for treatment of Athelete’s foot. Fungi contain cell wall made up of beta-1-3-glucan, other glucans and gylcoprotein. Below the cell wall there is a…
An interesting concept is that typically enzymes have been thought of as proteins that have catalytic properties. However, it would be very useful to have catalyst that is not damaged by heat, pH or other proteins that affect a typical protein. A science that is evolving is to create these novel materials that are different…
PROTAC (Proteolysis targeting chimera) is fantastic technology that can degrade specific proteins. It uses a small molecule with a capability to bind the protein to be degraded and an active site that binds to E3 ubiquitin ligase. Using the PROTAC pulls the protein into ubiquitin based degradation pathways by ubiquitination of the protein and subsequent…
Drug Discovery is expensive and many pharmaceutical companies make sure that the process is followed through all the steps including the ability to get their investment back from drug discovery. Janssen just got the FDA approval for tuberculosis. However, their motive was very different. There are only few hundred patients with drug resistant TB (tuberculosis)…
Drug Discovery is obviously expensive but the scientists that actually make the discoveries, make very little money. Yes, they might get a bonus or two but it is nowhere close to what the Vice President of the President of the division will make, who get a decent compensation package with stock options and other bonuses….
Nearly 100 cancer physicians had published a report in Blood that the prices of drugs for cancer that typically cost about $100,000 per year are unsustainable and something needs to be done to manage that for the patients. The article is worth a read and compares a UK study which typically puts as a life…
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