Another look at the financial data of Pharmaceutical companies. Who has the big bucks to spend on research? A picture is worth a thousand words.

Another look at the financial data of Pharmaceutical companies. Who has the big bucks to spend on research? A picture is worth a thousand words.

There are many reactions in biology that are catalyzed by enzymes but there are other reactions in industrial chemistry that use industrial catalysts which have primarily been platinum based. A paper in Nature https://www.nature.com/articles/s41467-026-68432-1 promises a unique shaped catalyst that can split H-H bond and other reactions. It is a unique structure and promises to…
Schizophrenia is mental disorder characterized by problems in thinking, perception, emotions and behavior. It requires long term medication to manage symptoms. There are many drugs in the market to treat schizophrenia: Antipsychotics: These block the dopamine D2 receptor, though with side effects such as tremors and tardive dyskinesia. The Atypical antipsychotics affect both the dopamine…
There are many AI tools for Cheminformatics and it takes a while to learn. Pat Walters has been practicing and teaching chemoinformatics and is a great resource. His GitHub page also has many tutorials. Worth a listen and read. https://github.com/PatWalters/practical_cheminformatics_tutorials
PROTAC (Proteolysis targeting chimera) is fantastic technology that can degrade specific proteins. It uses a small molecule with a capability to bind the protein to be degraded and an active site that binds to E3 ubiquitin ligase. Using the PROTAC pulls the protein into ubiquitin based degradation pathways by ubiquitination of the protein and subsequent…
An interesting concept is that typically enzymes have been thought of as proteins that have catalytic properties. However, it would be very useful to have catalyst that is not damaged by heat, pH or other proteins that affect a typical protein. A science that is evolving is to create these novel materials that are different…
As more drugs are discovered, it is often assumed that we understand the logical mechanisms of how drug acts on specific physiology and in terms of bacteria and virus, how that drug inhibits the growth or survival of the microbe. However, in many cases the mechanism of action is understood much later. In the early…
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