Bayes methods have come to microscopy. Researchers have developed the Bayesian analysis of photo-blinking and photo-bleaching in microscopy to deduce the structure that is not usually visible. (Bayesian localization microscopy reveals nanoscale podosome dynamics, Cox, S et al, Nat. Methods 9, 195 (2012)) http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.1812.html There have been many methods that are used for super resolution…
As we move towards an era of robots, improvements in the design piece by piece takes place as the roboticists go along in their endeavors. Roboticists are using reptiles, ants and even grasshoppers as templates for the automatons, learning from the ways these non-human models have evolved in their ways of navigation, balance and stability….
Cloud computing is a very useful if you are processing large amount of data and cannot wait for your results or these are clinical and mission critical operations. However, there are several steps you need to understand before using it for imaging. The factors that affect most calculations for cost and use are: RAM: Random…
When Pharmaceutical company discover new molecules that are going to become a drug, there is an obvious step where they manufacture the API – Active Pharmaceutical Ingredient, but beyond that, they also need to make sure that the drug is packaged right as a tablet or capsule, is bio-available and there is a big branch…
Andreas Velten at MIT has been working in the lab of Ramesh Raskar to develop a camera that captures almost at the speed of light. This work was inspired by the bullet through the apple pictures by Doc Edgerton also at MIT. Their work is fascinating to see on Andreas website but it is hard…
Tufts Center for the Study of Drug Development does research on drug development and publishes regular reports on drug development. The reports are primarily research conducting by the Center on the current trends in drug development, meetings, forums, courses and discussions. They do not come up with novel methods for drug development but rather act…
In the field of imaging there is another branch of image acquisition/analysis/study that is called Computational Photography as distinguished from traditional photography. In traditional photography, with a regular camera, you take a picture of a 3D scene through a camera. This light from the scene is captured as a 2-dimensional representation onto a photo-sensitive surface,…
Take an example of failed target validation. Eli Lilly is just one company but this could be true of almost all the pharmaceutical companies. Eli Lilly announced in August 2012, that they have stopped “ongoing clinical studies investigating pomaglumetad methionil, also known as mGlu2/3, for the treatment of patients suffering from schizophrenia” in Phase 3….
When a coherent laser hits a surface, the laser light is diffracted in all directions. It is easy to take a laser pointer and do this experiment. The pattern that is emitted is a complex dotted pattern of bright and dark intensities. These intensities appear random but are actually a property of the material and…
In gene knockout studies, scientists delete or stop expression of one gene and then check to see if that gene is required. In these studies, if a gene is critical – say for cell division then cells do not divide and the gene is termed essential, the mutations in that gene would be termed lethal…
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