Drug discovery is hard.
Amazing to see the databases that are available for public access that enable drug discovery. Broad institute publishes The Connectivity map (CMAP)which is a database of gene signatures of transcriptional response to perturbation of many cell lines. This is incredible amount of data that is available in the public domain to be mined.
Look up here: Connectivity Map (CMAP) | Broad Institute
Not only is the data available but all the resource to mine the data are also available. You can find out more here at: Subramanian A, et al. A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles. Cell. 2017/12/1. 171(6):1437–1452.
And if you go further there are more databases. And more tools. Let’s lookup a colon cancer database with Morpheus (MORPHEUS [clue.io]) which allows you to explore heat maps as the image above shows you.
And repositories for compounds that will help you to repurpose drugs that are specific for the target that may interest you. See Metformin below
