Mindblown: a blog about philosophy.
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Luminscence based cell imaging and sensors – Nanolantern
In cell imaging, the most often used proteins are the Fluorescent proteins like (Green Fluorescent Protein}, GFP or many other fluorescent proteins like Yellow-FP, Blue-FP. They are popular because it is possible to express a labeled protein directly inside the cell. Before the discovery of fluorescent proteins, the only method was to express the protein,…
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Developmental disorders and EEG
It has been assumed that the developmental disorders in some children are something that they are born with and cannot be changed. The case in point is autism. Though there are many companies working on it there has been not much therapeutic progress. Dr Aditi Shankardass has been pioneering the use of a common EEG…
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Locked in syndrome – technologies for communication
A stroke is a major cause of death but in non-lethal cases it causes significant damage to the brain. One of the most bizarre one is the locked-in syndrome. This is caused by the lesion to the brain stem ventral pons and was termed the “locked in syndrome” by Plum and Posner in 1966. There…
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Provisional patent application – How to file your own?
USA moves the first to file patent system on March 16, 2013 after the enactment of the America Invents Act so file your patents NOW! You have to file your patent claim to get advantage of your patent. A provisional patent is a simple inexpensive document to preserve your rights to an invention while giving…
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Single molecule super resolution microscopy made simple
Bayes methods have come to microscopy. Researchers have developed the Bayesian analysis of photo-blinking and photo-bleaching in microscopy to deduce the structure that is not usually visible. (Bayesian localization microscopy reveals nanoscale podosome dynamics, Cox, S et al, Nat. Methods 9, 195 (2012)) http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.1812.html There have been many methods that are used for super resolution…
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Tailbots and Stickybots
As we move towards an era of robots, improvements in the design piece by piece takes place as the roboticists go along in their endeavors. Roboticists are using reptiles, ants and even grasshoppers as templates for the automatons, learning from the ways these non-human models have evolved in their ways of navigation, balance and stability.…
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Cloud computing for imaging.
Cloud computing is a very useful if you are processing large amount of data and cannot wait for your results or these are clinical and mission critical operations. However, there are several steps you need to understand before using it for imaging. The factors that affect most calculations for cost and use are: RAM: Random…
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Coating of Pharmaceutical ingredients
When Pharmaceutical company discover new molecules that are going to become a drug, there is an obvious step where they manufacture the API – Active Pharmaceutical Ingredient, but beyond that, they also need to make sure that the drug is packaged right as a tablet or capsule, is bio-available and there is a big branch…
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Camera – Trillion frames a second.
Andreas Velten at MIT has been working in the lab of Ramesh Raskar to develop a camera that captures almost at the speed of light. This work was inspired by the bullet through the apple pictures by Doc Edgerton also at MIT. Their work is fascinating to see on Andreas website but it is hard…
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Outlook for Pharmaceuticals for 2013 – Tufts
Tufts Center for the Study of Drug Development does research on drug development and publishes regular reports on drug development. The reports are primarily research conducting by the Center on the current trends in drug development, meetings, forums, courses and discussions. They do not come up with novel methods for drug development but rather act…
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