See the link below for a disease that has affected about 100 people in the US since 1960. It is contracted by swimming in a few lakes which have sediment that can stir up amoeba. This amoeba called Naegleria Fowlerie and can infect the neurons through the nasal cavity. Eating their way through neurons from…
It has always been argued that breakdown in homeostasis is the real cause of disease. This point is amply illustrated by the recent PNAS article that correlated the miniscule amounts of copper in the mice diet with A-beta clearance and would have an implication for Alzheimer’s disease. In this case, the presence of copper affected…
There are several ways to look at development: The Lego way used to be that the best is good enough in the book “Brick by Brick” with the assumption being that the product has to be perfect before it is made available to the general public. However, the second line of thought is that the…
Targets for cancer therapy initially were very specific cell division targets. Nowadays, the targets have become very cancer specific, for e.g. targeting the BCR-ABL to target Chronic Myeloid Leukemia. However, a scientist in Australia has come up with a target that is very unlikely – tropomyosin. Tropomyosin is a protein that along with actin is…
Fortune highlighted Regeneron for its ability to do drug discovery for much less. To quote from their article here are the costs for drug development by some of the Big Pharma: Merck : $5.5 Billion per drug Pfizer: $7.8 Billion Sanofi: $10 Billion Average for other Pharma: $4.3 Billion Regeneron: $0.75 Billion There may be…
Cellular automata are more of a computer based concept wherein a “cell” that is created in virtual screen dependent on the neighbors. Its creation or destruction is dependent on the type of neighbors. This leads to interesting displays, dynamic scenario’s, that are always dynamic since the neighbor’s affect their other neighbors and the effect continues…
Much of biological science and technologies are trying to cure disease. However, there are a large group of people who do not want to be cured. There are several instances and examples where they have objected vehemently about not doing things that would cure their ailment. What ailment ? Deafness. Deafness has been cured to…
Drug Discovery is obviously expensive but the scientists that actually make the discoveries, make very little money. Yes, they might get a bonus or two but it is nowhere close to what the Vice President of the President of the division will make, who get a decent compensation package with stock options and other bonuses….
Cancer is a difficult disease to manage but still difficult to treat. However, many people have many thoughts on what it takes to cure disease and cure it. Maybe, some of them are practical and others are no so practical, however, it will take a revolutionary approach to come up drug discovery paradigms that help…
Drug Discovery is expensive. Even drugs for an important disease like cancer have not been as easy to discover. There are many reasons and that could be a topic for a separate article but an MIT professor, Andrew Lo has proposed a new model. In the present model, all drug discoveries are funded…
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