Biomarker

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    Relaxin

    Byscientist

    Relaxin is a 6kd 2 chain peptide hormone produced by ovary and placenta in females tha help remodel connective tissue but also promotes vasodilation and has cardioprotective and renoprotective effects in animal model via Nitric oxide pathway. Relaxin-2 signaling via GPCR RXFP1 has been investigated as a drug for its antifibrotic and vasodilatory actions. RXFP1…

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    Biotech companies

    Byscientist

    Small Biotechs: Diagonal Tx: Clustering antibodies that mimic the action of the ligand and bypass the need for the ligand and receptor. This mutation that is created makes standard AI models not useful and so need a new method. This restores new ALK1 signaling in Hereditary Hemorrhagic Telangiectasia. It also treates LoF mutations in ALK1…

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    Sequencing

    Byscientist

    It is amazing how good genetic sequencing is getting these days and reasonable enough to get 30x whole genome sequence that enables detailed analysis for a variety of conditions. The costs are so low that it is now possible for almost everyone to do it and also analyze the data. One provider with a catchy…

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    Bile duct cancer

    Byscientist

    Bile duct cancer or cholangiocarcinoma, (CCA) is a rare cancer with an incidence of ~3 cases per 100,000 with 10,000 new case diagnosed annually. It is about 10-20% of liver cancers. Interestingly, in Thailand, and some south east asian countries, the incidence is nearly 10 fold higher due to liver fluke infections (Opisthorchis viverrini and…

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    Bisphenol A

    Byscientist

    There is lot of information on BPA on wikipedia that talks about its use in plastics especially polycarbonates that are used in water bottle manufacturing. Polycarbonate bottles are transparent and can contain 90% BPA by mass It is not a plasticizer. The concern for its use comes from its effect as a weak xenoestrogen disrupting…

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    Hypertension

    Byscientist

    There are many therapies for regulating high blood pressure. The one that has received some attention is the natural therapy by consumption of beet in various forms. Juice, raw, tablets, and cooked. The primary benefit appears to be conferred by the presence of nitrates, which enhance the amount of Nitric oxide present in blood and…

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    TDP43

    Byscientist

    TDP43 (a nuclear DNA-RNA binding protein) is involved in splicing, RNA transport and stability in neurons. It was first identified as a pyrimidine rich TAR DNA sequence in HIV type 1 gene to modulate HIV gene expression. In 95% of the ALS patients, TDP43 is abnormal located within the cell and may also be aggregated,…

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    Sleep apnea

    Byscientist

    Sleep apnea is when sufferer stops breathing (apnea) at night as the muscles in the throat relax and then resumes when brain semi-awakes when the oxygen supply gets low to restore respiration. This happens tens to hundreds of times at night and can be debilitating when the disruption to sleep causes other health effects such…