It is well known in literature that the surface topography has a profound effect on immune reaction – for example some rough surfaces of implants can create some very bad adverse reactions. Similarly, there is good published literature from 1978 (Folkman and Mosconna) that showed that different concentrations of poly(2-hydroxethyl methacrylate) influenced the cell shape and hence affected cell division. In addition, literature from 2004 (Chen et al) showed that a mesenchymal stromal cell can become fat or bone dependent on shape of the cell.
However, since it is very difficult to try out shapes through tedious trial and error, a group of researchers have come up with a great idea to create a library of shapes that can be used to quickly screen for shapes that are relevant in affecting cell fate. This library may or may not find that perfect shape that induces cell division but it could be very relevant in screening out shapes that are very antagonistic to the immune system. Additionally, it is possible that these shapes might have additional beneficial effects. It remains to be determined whether the shape induced changes induced with cells or immune system is all mediated through one pathway like Rho A signaling . It will also be interesting to observe whether specific drug inhibitors in combination with specific shapes could have other effects on cells and eventually influence treatment modalities.
See the video below and follow the very interesting link.
{vimeo}28654960{/vimeo}